Zhang, H., Alder, N.N., Wang, W., Szeto, H., Marcinek, D.J., and Rabinovitch, P.S. (2020) Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte. Elife 9:e60827
Mitchell, W., Ng, E.A., Tamucci, J.D., Boyd, K.J., Sathappa, M., Coscia, A., Pan, M., Han, X., Eddy, H.A., May, E.R., Szeto, H.H., and Alder, N.N. (2020) The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action. Journal of Biological Chemistry 295: 7452
Bae, M., Lee, Y., Park, Y.K., Shin, D.G., Joshi, P., Hong, S.H., Alder, N., Koo, S.I., and Lee, J.Y. (2019) Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells. Journal of Nutritional Biochemistry 71: 82
Calzada, E., Avery, E., Sam, P.N., Modak, A., Wang, C., McCaffery, J.M., Han, X., Alder, N.N., and Claypool, S.M. (2019) Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function. Nature Communications 10: 1432
Alder, N.N. (2019) Fluorescence spectroscopy and its applications in analyzing biomolecular processes. In: Biomolecular and Bioanalytical Techniques: Theory, Methodology and Applications
Alder Lab News
- New Grant from the NIAThe Alder Research Group has received an R01 grant the National Institute of Aging (R01AG065879, “First-in-class Peptide Therapeutics for Mitochondrial Disorders: Molecular Mechanism of Action and Optimization of Design”). This is a five-year grant in the amount of $2.5M to support the development and analysis of therapeutic compounds for aging-related mitochondrial disorders.
- New Grant from the Barth Syndrome FoundationWe have received a $50K grant from the Barth Syndrome Foundation, “Development of Mitochondria-Targeted Peptide Compounds as Barth Syndrome Therapeutics. This work will explore a library of compound variants optimized as therapeutics for treating dysfunctional lipid biogenesis of Barth Syndrome patients.
- New Grant from NIGMSThe Alder Group has received an R01 grant from NIH General Medical Sciences (R01GM136975 , “Mitochondrial Membrane Compartmentalization”) for $774K over two years. This is a multi-PI grant with the group of Dr. Steven Claypool from the Johns Hopkins University School of Medicine.
- New PhD GraduatePhD candidate Melissa Brundin has completed her dissertation “Investigation of the Protein-Membrane Interactions of the Tim23 Channel Subunit” and did a remarkable job at her defense. Congratulations, soon-to-be Dr. Brundin!