Alder Lab

Research Themes

New Publications

Zhao, T., Alder, N.N., Starkweather, A.R., Chen, M.H., Matson, A.P., Xu, W., Balsbaugh, J.L., and Cong, X. (2022) Associations of mitochondrial function, stress, and neurodevelopmental outcomes in early life: a systematic review. Developmental Neuroscience 44: 438-454

Mitchell, W., Tamucci, J.D., Ng, E.L., Liu, S., Birk, A.V., Szeto, H.H., May, E.R., Alexandrescu, A.T., and Alder, N.N. (2022) Structure-activity relationships of mitochondria-targeted pharmacological compounds. Elife 11:e75531

Iovine, J.C., Claypool, S.M., and Alder, N.N. (2021) Mitochondrial compartmentalization: emerging themes in structure and function. Trends in Biochemical Sciences 46: 902-917

Zhang, H., Alder, N.N., Wang, W., Szeto, H., Marcinek, D.J., and Rabinovitch, P.S. (2020) Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte. Elife 9:e60827

Mitchell, W., Ng, E.A., Tamucci, J.D., Boyd, K.J., Sathappa, M., Coscia, A., Pan, M., Han, X., Eddy, H.A., May, E.R., Szeto, H.H., and Alder, N.N. (2020) The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action. Journal of Biological Chemistry 295: 7452

 

Alder Lab News

  • New Grant from the NIA
    The Alder Research Group has received an R01 grant the National Institute of Aging (R01AG065879, “First-in-class Peptide Therapeutics for Mitochondrial Disorders: Molecular Mechanism of Action and Optimization of Design”). This is a five-year grant in the amount of $2.5M to support the development and analysis of therapeutic compounds for aging-related mitochondrial disorders.
  • New Grant from the Barth Syndrome Foundation
    We have received a $50K grant from the Barth Syndrome Foundation, “Development of Mitochondria-Targeted Peptide Compounds as Barth Syndrome Therapeutics. This work will explore a library of compound variants optimized as therapeutics for treating dysfunctional lipid biogenesis of Barth Syndrome patients.
  • New Grant from NIGMS
    The Alder Group has received an R01 grant from NIH General Medical Sciences (R01GM136975 , “Mitochondrial Membrane Compartmentalization”) for $774K over two years. This is a multi-PI grant with the group of Dr. Steven Claypool from the Johns Hopkins University School of Medicine.
  • New PhD Graduate
    PhD candidate Melissa Brundin has completed her dissertation “Investigation of the Protein-Membrane Interactions of the Tim23 Channel Subunit” and did a remarkable job at her defense. Congratulations, soon-to-be Dr. Brundin!

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We are an academic science lab studying the role of mitochondria in human health and disease.

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